The study examined gender, stress and locus of control as predictors of depression among Ebonyi State University non-academic staff. Two hundred and forty-four (244) Ebonyi State University non-academic staff comprising males 121 and females 123 drawn randomly from selected administrative units of Ebonyi State University, Abakaliki participated. Their ages ranged from 20 to 65 years with a mean age of 38.25 years (SD = 3.26). Cross sectional survey design was adopted. Three hypotheses were tested using hierarchical multiple regression. Result showed that locus of control significantly predicted depression among adults. The result also showed that stress significantly predicted depression among Ebonyi State University non-academic staff. But gender did not predict depression among Ebonyi State University non-academic staff. It was recommended that stress level be regularly monitored, orientation towards understanding how to manage events in peoples lives should be provided amng others.